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PMID: 22580472 Published · ppublish English Journal Article Review

The emerging functions of the p53-miRNA network in stem cell biology.

Cell cycle (Georgetown, Tex.) ·Vol. 11 ·No. 11 ·2012-06-01 ·Pages 2063-72

Lin CP, Choi YJ, Hicks GG, He L

Abstract

The p53 pathway plays an essential role in tumor suppression, regulating multiple cellular processes coordinately to maintain genome integrity in both somatic cells and stem cells. Despite decades of research dedicated to p53 function in differentiated somatic cells, we are just starting to understand the complexity of the p53 pathway in the biology of pluripotent stem cells and tissue stem cells. Recent studies have demonstrated that p53 suppresses proliferation, promotes differentiation of embryonic stem (ES) cells and constitutes an important barrier to somatic reprogramming. In addition, emerging evidence reveals the role of the p53 network in the self-renewal, proliferation and genomic integrity of adult stem cells. Interestingly, non-coding RNAs, and microRNAs in particular, are integral components of the p53 network, regulating multiple p53-controlled biological processes to modulate the self-renewal and differentiation potential of a variety of stem cells. Thus, elucidation of the p53-miRNA axis in stem cell biology may generate profound insights into the mechanistic overlap between malignant transformation and stem cell biology.

MeSH Terms
Adult Stem Cells/cytology,metabolism Cellular Reprogramming Humans MicroRNAs/metabolism Pluripotent Stem Cells/cytology,metabolism Stem Cells/cytology,metabolism Tumor Suppressor Protein p53/metabolism
Chemicals
MicroRNAs Tumor Suppressor Protein p53
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lin Chao-Po
Division of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, CA, USA.
Choi Yong Jin
Hicks Geoffrey G
He Lin
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Article Info
Journal
Cell cycle (Georgetown, Tex.)
Abbr.
Cell Cycle
ISSN
1551-4005
DOI
10.4161/cc.20207
Published
2012-06-01
Epub
2012-00-01
Pages
2063-72
Language
English
Region
United States
NLM ID
101137841
PMCID
PMC3368858
Subset
IM
Grants
NCI NIH HHS · R01 CA139067 · United States
External Links
PubMed source DOI: 10.4161/cc.20207 PMC Full Text View journal details
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