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PMID: 2257873 Published · ppublish English Journal Article

Influence of food on the bioavailability of metoprolol from an OROS system; a study in healthy volunteers.

European journal of clinical pharmacology ·Vol. 39 ·No. 3 ·1990-00-00 ·Pages 315-6

van den Berg G, van Steveninck F, Gubbens-Stibbe JM, Schoemaker HC, de Boer AG, Cohen AF

Abstract

The influence of food intake on the bioavailability of metoprolol from an OROS system has been investigated. No significant difference was found between OROS administration to fasting subjects or after breakfast in any of the kinetic parameters (AUC, Cmax, tmax, C24 and lag time). Therefore, metoprolol OROS can be administered with breakfast.

MeSH Terms
Administration, Oral Adult Biological Availability Delayed-Action Preparations Food Humans Male Metoprolol/administration & dosage,pharmacokinetics Random Allocation
Chemicals
Delayed-Action Preparations Metoprolol
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
van den Berg G
Centre for Human Drug Research, University Hospital Leiden, The Netherlands.
van Steveninck F
Gubbens-Stibbe J M
Schoemaker H C
de Boer A G
Cohen A F
References (4)
4 references, click to expand
  1. Investigation of drug absorption from the gastrointestinal tract of man. II. Metoprolol in the jejunum and ileum.
    Br J Clin Pharmacol. 1985;19 Suppl 2:107S-112S PMID: 4005111
  2. Influence of food intake on plasma oxprenolol concentrations following oral administration of conventional and Oros preparations.
    Br J Clin Pharmacol. 1985;19 Suppl 2:191S-195S PMID: 4005122
  3. Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.
    Br J Clin Pharmacol. 1985;19 Suppl 2:97S-105S PMID: 4005135
  4. Clinical pharmacokinetics of metoprolol.
    Clin Pharmacokinet. 1980 Nov-Dec;5(6):557-69 PMID: 7002420
Article Info
Journal
European journal of clinical pharmacology
Abbr.
Eur J Clin Pharmacol
ISSN
0031-6970
DOI
10.1007/BF00315121
Published
1990-00-00
Pages
315-6
Language
English
Region
Germany
NLM ID
1256165
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00315121 View journal details
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