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题目:: Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents.
作者:: Tasidou(Anna),Roussou(Maria),Terpos(Evangelos),Kastritis(Efstathios),Gkotzamanidou(Maria),Gavriatopoulou(Maria),Migkou(Magdalini),Eleutherakis-Papaiakovou(Evangelos),Nikitas(Nikitas),Anagnostou(Dimitra),Dimopoulos(Meletios A)
状态:: 发布时间2012-06-14 , 更新时间 2015-11-19
期刊:: Am J Hematol
摘要:: Multiple myeloma (MM) comprises 1% of all malignancies and 13% of hematological malignancies in the Caucasian population. Yearly incidence is 4/100,000 in the US and is higher in blacks and males [1]. The pathogenesis of the disease is relatively unknown; several chromosomal abnormalities have been related to the development of the disease,but none is characteristic of MM. Cyclin-D1 is a protein encoded by the CCND1 (bcl-1) gene on chromosome 11q13, and is an important regulator of G1 to S phase progression.
语言:: eng
DOI:: 10.1002/ajh.23223

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