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PMID: 22511918 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

The co-morbidity burden of children and young adults with autism spectrum disorders.

PloS one ·Vol. 7 ·No. 4 ·2012-00-00 ·Pages e33224

Kohane IS, McMurry A, Weber G, MacFadden D, Rappaport L, Kunkel L, Bickel J, Wattanasin N, Spence S, Murphy S, Churchill S

Abstract

Use electronic health records Autism Spectrum Disorder (ASD) to assess the comorbidity burden of ASD in children and young adults. A retrospective prevalence study was performed using a distributed query system across three general hospitals and one pediatric hospital. Over 14,000 individuals under age 35 with ASD were characterized by their co-morbidities and conversely, the prevalence of ASD within these comorbidities was measured. The comorbidity prevalence of the younger (Age<18 years) and older (Age 18-34 years) individuals with ASD was compared. 19.44% of ASD patients had epilepsy as compared to 2.19% in the overall hospital population (95% confidence interval for difference in percentages 13.58-14.69%), 2.43% of ASD with schizophrenia vs. 0.24% in the hospital population (95% CI 1.89-2.39%), inflammatory bowel disease (IBD) 0.83% vs. 0.54% (95% CI 0.13-0.43%), bowel disorders (without IBD) 11.74% vs. 4.5% (95% CI 5.72-6.68%), CNS/cranial anomalies 12.45% vs. 1.19% (95% CI 9.41-10.38%), diabetes mellitus type I (DM1) 0.79% vs. 0.34% (95% CI 0.3-0.6%), muscular dystrophy 0.47% vs 0.05% (95% CI 0.26-0.49%), sleep disorders 1.12% vs. 0.14% (95% CI 0.79-1.14%). Autoimmune disorders (excluding DM1 and IBD) were not significantly different at 0.67% vs. 0.68% (95% CI -0.14-0.13%). Three of the studied comorbidities increased significantly when comparing ages 0-17 vs 18-34 with p<0.001: Schizophrenia (1.43% vs. 8.76%), diabetes mellitus type I (0.67% vs. 2.08%), IBD (0.68% vs. 1.99%) whereas sleeping disorders, bowel disorders (without IBD) and epilepsy did not change significantly. The comorbidities of ASD encompass disease states that are significantly overrepresented in ASD with respect to even the patient populations of tertiary health centers. This burden of comorbidities goes well beyond those routinely managed in developmental medicine centers and requires broad multidisciplinary management that payors and providers will have to plan for.

MeSH Terms
Adolescent Adult Boston Child Child Development Disorders, Pervasive/epidemiology Child, Preschool Cohort Studies Comorbidity Electronic Health Records Female Humans Infant Infant, Newborn Male Prevalence Sex Ratio
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Kohane Isaac S
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America. Isaac_kohane@harvard.edu
McMurry Andrew
Weber Griffin
MacFadden Douglas
Rappaport Leonard
Kunkel Louis
Bickel Jonathan
Wattanasin Nich
Spence Sarah
Murphy Shawn
Churchill Susanne
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Article Info
Journal
PloS one
Abbr.
PLoS One
ISSN
1932-6203
DOI
10.1371/journal.pone.0033224
Email
isaac_kohane@harvard.edu
Published
2012-00-00
Epub
2012-00-12
Pages
e33224
Language
English
Region
United States
NLM ID
101285081
PMCID
PMC3325235
Subset
IM
Grants
NIMH NIH HHS · P50 MH094267 · United States
NIMH NIH HHS · P50MH94267 · United States
NCRR NIH HHS · 1UL1RR025758-01 · United States
NLM NIH HHS · U54 LM008748 · United States
NCRR NIH HHS · UL1 RR025758 · United States
External Links
PubMed source DOI: 10.1371/journal.pone.0033224 PMC Full Text View journal details
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