Targeting β-catenin in CML: leukemia stem cells beware!
作者:
Kleppe(Maria),Levine(Ross L)
状态:
发布时间2012-04-09
, 更新时间 2016-05-18
期刊:
Cell Stem Cell
摘要:
In this issue of Cell Stem Cell, Heidel et al. (2012) use genetic and pharmacological approaches to reveal that Wnt/β-catenin signaling is required for leukemic stem cell (LSC) maintenance in chronic myeloid leukemia. They demonstrate that β-catenin inactivation targets imanitib-resistant LSCs in vivo.