Generation of transplantable striatal projection neurons from human ESCs.
作者:
Parmar(Malin),Björklund(Anders)
状态:
发布时间2012-04-09
, 更新时间 2016-05-18
期刊:
Cell Stem Cell
摘要:
In this issue of Cell Stem Cell, Ma et al. (2012) report a differentiation protocol for generating striatal projection neurons from human embryonic stem cells with high efficiency. The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease.