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PMID: 22457928 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

A new lymphocyte alloantigen (Ly-10) controlled by a gene linked to the Lyt-1 locus.

Immunogenetics ·Vol. 10 ·No. 4 ·1980-00-00 ·Pages 363-72

Kimura S, Tada N, Hämmerling U

Abstract

Spleen cells from a (BALB/c x C57BL/6)F1 mouse immunized with CBA/J spleen cells were fused with the myeloma cell line NS-1. One of the six established hybrid cell lines continuously secreted antibody that recognized a new antigenic specificity, tentatively called "Ly-10.1". This newly found antigen is expressed on thymocytes, on splenic T and B cells, on bone-marrow cells, and on the cells derived from brain, kidney and liver. It is also expressed on a continuous cell line, 416B, with stem-cell characteristics. The unique tissue distribution and, furthermore, a distinct strain distribution pattern distinguishes Ly-10.1 from any known murine lymphocyte alloantigen. On the basis of reactivity with cells of the C57BL/6-Lyt-1a congenic strain, one gene governing Ly-10 expression is assigned to the Lyt-1 region of chromosome 19.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Antigens, Ly/genetics,immunology B-Lymphocytes/immunology CD5 Antigens/genetics,immunology Cytotoxicity Tests, Immunologic Epitopes/genetics,immunology Fusion Regulatory Protein 1, Heavy Chain/genetics,immunology Genetic Linkage Isoantigens/genetics,immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Spleen/cytology,immunology T-Lymphocytes/immunology Thymocytes/immunology Tissue Distribution/immunology
Chemicals
Antibodies, Monoclonal Antigens, Ly CD5 Antigens Cd5 protein, mouse Epitopes Fusion Regulatory Protein 1, Heavy Chain Isoantigens Slc3A2 protein, mouse
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kimura S
Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
Tada N
Hämmerling U
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24 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF01561586
Published
1980-00-00
Pages
363-72
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Grants
NIAID NIH HHS · AI 14831 · United States
NCI NIH HHS · CA 07848 · United States
NCI NIH HHS · CA25508 · United States
External Links
PubMed source DOI: 10.1007/BF01561586 View journal details
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