Collagenase--a marker enzyme in human bladder cancer?

Urological research ·Vol. 7 ·No. 2 ·1979-06-22 ·Pages 103-8

Wirl G, Frick J

Abstract

Collagenase activity in human bladder carcinomas was measured against 14C-labeled collagen as substrate. Enzymes activity in vivo increased with the degree of penetration of the bladder wall. It was not detectable or low in the cases of superficially infiltrating tumours (A, B1 B2) and high in the cases of deeply infiltrating tumours (C, D). These results suggest that collagenase activity of advanced tumours is predominantly expressed in the pervesical layer of the bladder wall. A quantitative estimate of this enzyme may thus help to distinguish between Stage C and Stage C tumour.

MeSH Terms

Adenocarcinoma/enzymology Female Humans In Vitro Techniques Kidney Neoplasms/enzymology Male Microbial Collagenase/metabolism Prostatic Neoplasms/enzymology Urinary Bladder Neoplasms/enzymology Uterine Cervical Neoplasms/enzymology

Chemicals

Microbial Collagenase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wirl G

Frick J

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30 references, click to expand

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Article Info

Journal

Urological research

Abbr.

Urol Res

ISSN

0300-5623

DOI

10.1007/BF00254689

Published

1979-06-22

Pages

103-8

Language

English

Region

Germany

NLM ID

0364311

Subset

External Links

PubMed source DOI: 10.1007/BF00254689 View journal details

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Collagenase--a marker enzyme in human bladder cancer?

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