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PMID: 2239154 Published · ppublish English Journal Article

Expression of monoamine oxidase B activity in astrocytes of senile plaques.

Acta neuropathologica ·Vol. 80 ·No. 4 ·1990-00-00 ·Pages 419-25

Nakamura S, Kawamata T, Akiguchi I, Kameyama M, Nakamura N, Kimura H

Abstract

Monoamine oxidase (MAO) histochemistry has been performed in brains from patients with dementia of Alzheimer type (DAT) and aged controls. Conspicuous MAO-positive cell clusters were frequently observed in the amygdala, hippocampus, and insular cortex in the brains of DAT. Double staining with glial fibrillary acidic protein immunohistochemistry revealed that the cluster-forming MAO-positive cells were astrocytes. Using Bielschowsky's method, Congo red and thioflavin S counterstaining, this astrocytic mass was shown to be associated with senile plaques. By the enzyme inhibition experiment, MAO activity in senile plaques was revealed to be of type B. The present results clearly indicate that MAO-B activity is expressed in fibrillary astrocytes in or around senile plaques, suggesting that these astrocytes metabolize exogenous amines in senile plaques.

MeSH Terms
Aged Aged, 80 and over Alzheimer Disease/enzymology,pathology Astrocytes/enzymology,ultrastructure Brain/enzymology,ultrastructure Dementia/enzymology,pathology Female Humans Male Monoamine Oxidase/analysis
Chemicals
Monoamine Oxidase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Nakamura S
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Kawamata T
Akiguchi I
Kameyama M
Nakamura N
Kimura H
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00307697
Published
1990-00-00
Pages
419-25
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00307697 View journal details
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