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题目:: Intrinsic regenerative potential of murine cochlear supporting cells.
作者:: Sinkkonen(Saku T),Chai(Renjie),Jan(Taha A),Hartman(Byron H),Laske(Roman D),Gahlen(Felix),Sinkkonen(Wera),Cheng(Alan G),Oshima(Kazuo),Heller(Stefan)
状态:: 发布时间2012-02-22 , 更新时间 2016-10-19
期刊:: Sci Rep
摘要:: The lack of cochlear regenerative potential is the main cause for the permanence of hearing loss. Albeit quiescent in vivo, dissociated non-sensory cells from the neonatal cochlea proliferate and show ability to generate hair cell-like cells in vitro. Only a few non-sensory cell-derived colonies, however, give rise to hair cell-like cells, suggesting that sensory progenitor cells are a subpopulation of proliferating non-sensory cells. Here we purify from the neonatal mouse cochlea four different non-sensory cell populations by fluorescence-activated cell sorting (FACS). All four populations displayed proliferative potential, but only lesser epithelial ridge and supporting cells robustly gave rise to hair cell marker-positive cells. These results suggest that cochlear supporting cells and cells of the lesser epithelial ridge show robust potential to de-differentiate into prosensory cells that proliferate and undergo differentiation in similar fashion to native prosensory cells of the developing inner ear.
语言:: eng
DOI:

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