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PMID: 22345482 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells.

Journal of virology ·Vol. 86 ·No. 8 ·2012-04-00 ·Pages 4701-7

Salamon D, Adori M, Ujvari D, Wu L, Kis LL, Madapura HS, Nagy N, Klein G, Klein E

Abstract

We report that type I interferons (IFNs) upregulate latent membrane protein 1 (LMP-1) expression by direct activation of the ED-L1 promoter in several Epstein-Barr virus (EBV)-carrying Burkitt's lymphoma lines. In EBV-infected primary B cells, IFN-α transiently upregulates LMP-1 mRNA, but not protein levels, followed by downregulation of both, suggesting a novel antiproliferative mechanism of type I IFNs. Furthermore, our results may explain the expression of LMP-1 in memory B cells of systemic lupus erythematosus patients.

MeSH Terms
B-Lymphocytes/drug effects,metabolism,virology Cell Line Gene Expression Regulation, Viral/drug effects Herpesvirus 4, Human/genetics,immunology Humans Interferon Type I/metabolism,pharmacology Molecular Sequence Data Promoter Regions, Genetic Signal Transduction/drug effects Transcription, Genetic Viral Matrix Proteins/genetics,metabolism Virus Latency
Chemicals
EBV-associated membrane antigen, Epstein-Barr virus Interferon Type I Viral Matrix Proteins
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Salamon Daniel
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Daniel.Salamon@ki.se
Adori Monika
Ujvari Dorina
Wu Liang
Kis Lorand L
Madapura Harsha S
Nagy Noemi
Klein George
Klein Eva
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
1098-5514
DOI
10.1128/JVI.06829-11
Email
daniel.salamon@ki.se
Published
2012-04-00
Epub
2012-00-15
Pages
4701-7
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC3318621
Subset
IM
Databases
GENBANK
HE653895, HE653896
External Links
PubMed source DOI: 10.1128/JVI.06829-11 PMC Full Text View journal details
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