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PMID: 2234057 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways.

Nature ·Vol. 348 ·No. 6296 ·1990-11-01 ·Pages 39-44

Teyton L, O'Sullivan D, Dickson PW, Lotteau V, Sette A, Fink P, Peterson PA

Abstract

Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease.

MeSH Terms
Amino Acid Sequence Animals Antigen-Presenting Cells/immunology Antigens, Differentiation, B-Lymphocyte Base Sequence Binding, Competitive DNA/genetics Endocytosis Endoplasmic Reticulum/metabolism HLA-DQ Antigens/immunology,metabolism HLA-DR Antigens/metabolism HeLa Cells Histocompatibility Antigens Class II/chemistry,genetics,immunology,metabolism Humans Immunosorbent Techniques Macromolecular Substances Membrane Proteins/immunology Molecular Sequence Data Peptides/immunology,metabolism Protein Sorting Signals/immunology T-Lymphocytes/immunology Transfection
Chemicals
Antigens, Differentiation, B-Lymphocyte HLA-DQ Antigens HLA-DQ8 antigen HLA-DR Antigens Histocompatibility Antigens Class II Macromolecular Substances Membrane Proteins Peptides Protein Sorting Signals invariant chain DNA
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Teyton L
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
O'Sullivan D
Dickson P W
Lotteau V
Sette A
Fink P
Peterson P A
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/348039a0
Published
1990-11-01
Pages
39-44
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/348039a0 View journal details
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