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PMID: 22337051 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Functional complexity and regulation through RNA dynamics.

Nature ·Vol. 482 ·No. 7385 ·2012-02-15 ·Pages 322-30

Dethoff EA, Chugh J, Mustoe AM, Al-Hashimi HM

Abstract

Changes to the conformation of coding and non-coding RNAs form the basis of elements of genetic regulation and provide an important source of complexity, which drives many of the fundamental processes of life. Although the structure of RNA is highly flexible, the underlying dynamics of RNA are robust and are limited to transitions between the few conformations that preserve favourable base-pairing and stacking interactions. The mechanisms by which cellular processes harness the intrinsic dynamic behaviour of RNA and use it within functionally productive pathways are complex. The versatile functions and ease by which it is integrated into a wide variety of genetic circuits and biochemical pathways suggests there is a general and fundamental role for RNA dynamics in cellular processes.

MeSH Terms
Base Sequence Models, Molecular Molecular Chaperones/metabolism Nucleic Acid Conformation RNA/chemistry,genetics,metabolism RNA Helicases/metabolism RNA, Untranslated/chemistry,genetics,metabolism Thermodynamics
Chemicals
Molecular Chaperones RNA, Untranslated RNA RNA Helicases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Dethoff Elizabeth A
Department of Chemistry and Biophysics, The University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA.
Chugh Jeetender
Mustoe Anthony M
Al-Hashimi Hashim M
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature10885
Published
2012-02-15
Epub
2012-00-15
Pages
322-30
Language
English
Region
England
NLM ID
0410462
PMCID
PMC3320162
Subset
IM
Grants
NIAID NIH HHS · R01 AI066975 · United States
NIAID NIH HHS · R01 AI066975-07 · United States
NIGMS NIH HHS · R01 GM089846 · United States
NIGMS NIH HHS · R01 GM089846-03 · United States
External Links
PubMed source DOI: 10.1038/nature10885 PMC Full Text View journal details
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