Parkinson's disease and cytochrome P450: a possible link?

Medical hypotheses ·Vol. 32 ·No. 4 ·1990-08-00 ·Pages 277-82

Shahi GS, Das NP, Moochhala SM

Abstract

The possibility that idiopathic Parkinson's disease may be linked to a deficiency of an important detoxifying enzyme such as the cytochrome P450 enzyme bufuralol hydroxylase is examined. A hypothetical model of how this might operate to produce early onset Parkinson's disease is suggested.

MeSH Terms

Brain/metabolism Cytochrome P-450 Enzyme System/deficiency Dopamine/metabolism Humans MPTP Poisoning Mixed Function Oxygenases/deficiency Models, Biological Parkinson Disease/enzymology,etiology Parkinson Disease, Secondary/chemically induced

Chemicals

Cytochrome P-450 Enzyme System Mixed Function Oxygenases bufuralol 1'-hydroxylase Dopamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Shahi G S

Department of Physiology, National University of Singapore.

Das N P

Moochhala S M

Article Info

Journal

Medical hypotheses

Abbr.

Med Hypotheses

ISSN

0306-9877

DOI

10.1016/0306-9877(90)90106-o

Published

1990-08-00

Pages

277-82

Language

English

Region

United States

NLM ID

7505668

Subset

External Links

PubMed source DOI: 10.1016/0306-9877(90)90106-o View journal details

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