Stem-cell-like qualities of immune memory; CD4+ T cells join the party.

Cell stem cell ·Vol. 10 ·No. 2 ·2012-02-03 ·Pages 107-8

Luckey CJ, Weaver CT

Abstract

Similar to hematopoietic stem cells, memory lymphocytes self-renew, while their clonally expanded effector progeny differentiate to fight infection and tumors. Recently, Muranski et al. (2011) report in Immunity that a subset of Th17 effector cells function as memory cells and retain stem cell properties.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Luckey C John

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. cluckey@partners.org

Weaver Casey T

References (10)

10 references, click to expand

Arrested differentiation, the self-renewing memory lymphocyte, and vaccination.
Science. 2001 Jul 13;293(5528):248-50 PMID: 11452114
Asymmetric T lymphocyte division in the initiation of adaptive immune responses.
Science. 2007 Mar 23;315(5819):1687-91 PMID: 17332376
Beta-catenin does not regulate memory T cell phenotype.
Nat Med. 2010 May;16(5):513-4; author reply 514-5 PMID: 20448567
Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.
Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3304-9 PMID: 16492737
Th17 cells are long lived and retain a stem cell-like molecular signature.
Immunity. 2011 Dec 23;35(6):972-85 PMID: 22177921
A human memory T cell subset with stem cell-like properties.
Nat Med. 2011 Sep 18;17(10):1290-7 PMID: 21926977
Developmental plasticity of Th17 and Treg cells.
Curr Opin Immunol. 2009 Jun;21(3):274-80 PMID: 19524429
Effector T cell plasticity: flexibility in the face of changing circumstances.
Nat Immunol. 2010 Aug;11(8):674-80 PMID: 20644573
Cutting edge: β-catenin is dispensable for T cell effector differentiation, memory formation, and recall responses.
J Immunol. 2011 Aug 15;187(4):1542-6 PMID: 21724993
Origins of CD4(+) effector and central memory T cells.
Nat Immunol. 2011 Jun;12(6):467-71 PMID: 21739668

Article Info

Journal

Cell stem cell

Abbr.

Cell Stem Cell

ISSN

1875-9777

DOI

10.1016/j.stem.2012.01.011

cluckey@partners.org

Published

2012-02-03

Pages

107-8

Language

English

Region

United States

NLM ID

101311472

PMCID

PMC3277283

Grants

NIDDK NIH HHS · R01 DK093015-01A1 · United States

NIAID NIH HHS · R21 AI095635-01 · United States

NIDDK NIH HHS · P01 DK071176-06S1 · United States

NIAID NIH HHS · R01 AI077574 · United States

NIAID NIH HHS · R01 AI077574-03 · United States

NIDDK NIH HHS · P01 DK071176 · United States

NIDDK NIH HHS · P01 DK044240 · United States

NIAID NIH HHS · R21 AI095635 · United States

NIDDK NIH HHS · R01 DK093015 · United States

Corrections

CommentOn

PMID: 22177921

External Links

PubMed source DOI: 10.1016/j.stem.2012.01.011 PMC Full Text View journal details

Analysis Services

Stem-cell-like qualities of immune memory; CD4+ T cells join the party.

Contact

WeChat Official Account