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PMID: 22272186 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Putting the pieces together: integrative modeling platform software for structure determination of macromolecular assemblies.

PLoS biology ·Vol. 10 ·No. 1 ·2012-01-00 ·Pages e1001244

Russel D, Lasker K, Webb B, Velázquez-Muriel J, Tjioe E, Schneidman-Duhovny D, Peterson B, Sali A

Abstract

A set of software tools for building and distributing models of macromolecular assemblies uses an integrative structure modeling approach, which casts the building of models as a computational optimization problem where information is encoded into a scoring function used to evaluate candidate models.

MeSH Terms
Computational Biology/methods Humans Macromolecular Substances/chemistry Models, Molecular RNA Polymerase II/chemistry Software
Chemicals
Macromolecular Substances RNA Polymerase II
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Russel Daniel
Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, San Francisco, California, United States of America.
Lasker Keren
Webb Ben
Velázquez-Muriel Javier
Tjioe Elina
Schneidman-Duhovny Dina
Peterson Bret
Sali Andrej
Conflict of Interest

The authors have declared that no competing interests exist.

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Article Info
Journal
PLoS biology
Abbr.
PLoS Biol
ISSN
1545-7885
DOI
10.1371/journal.pbio.1001244
Published
2012-01-00
Epub
2012-00-17
Pages
e1001244
Language
English
Region
United States
NLM ID
101183755
PMCID
PMC3260315
Subset
IM
Grants
NEI NIH HHS · PN2 EY016525 · United States
NIGMS NIH HHS · R01 GM083960 · United States
NCRR NIH HHS · U54 RR022220 · United States
External Links
PubMed source DOI: 10.1371/journal.pbio.1001244 PMC Full Text View journal details
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