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题目:: CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations.
作者:: Seok(Yoonmi),Kim(Juwon),Choi(Jong Rak),Kim(Yu Ri),Park(Seo-Jin),Kim(Sue Jung),Song(Jaewoo),Lee(Kyung-A)
状态:: 发布时间2012-01-19 , 更新时间 2015-01-28
期刊:: Ann Lab Med
摘要:: The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
语言:: eng
DOI:

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