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PMID: 22231116 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transcriptional regulation of Rho GTPase signaling.

Transcription ·Vol. 2 ·No. 5 ·2011-00-00 ·Pages 211-5

Croft DR, Olson MF

Abstract

Signaling through the Rho family of small GTPases regulates a variety of cellular processes via changes in the actin cytoskeleton. Here we discuss recent findings that show the transcription factor p53 regulates the expression of several Rho pathway signaling molecules, and how mutation of p53 in cancer dramatically alters signaling output through this pathway.

MeSH Terms
Actin Depolymerizing Factors/metabolism Actins/metabolism Apoptosis Cytoskeleton/metabolism DNA Damage Humans Lim Kinases/metabolism Neoplasms/metabolism,pathology Signal Transduction Transcription, Genetic Tumor Suppressor Protein p53/genetics,metabolism rho GTP-Binding Proteins/genetics,metabolism rho-Associated Kinases/metabolism rhoA GTP-Binding Protein/metabolism rhoB GTP-Binding Protein/metabolism rhoC GTP-Binding Protein
Chemicals
Actin Depolymerizing Factors Actins Tumor Suppressor Protein p53 LIMK1 protein, human Lim Kinases ROCK1 protein, human ROCK2 protein, human rho-Associated Kinases RHOC protein, human RND3 protein, human rho GTP-Binding Proteins rhoA GTP-Binding Protein rhoB GTP-Binding Protein rhoC GTP-Binding Protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Croft Daniel R
The Beatson Institute for Cancer Research, Garscube Estate; Glasgow, UK.
Olson Michael F
References (30)
30 references, click to expand
  1. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.
    Nature. 2007 Oct 11;449(7163):682-8 PMID: 17898713
  2. p53 and its mutants in tumor cell migration and invasion.
    J Cell Biol. 2011 Jan 24;192(2):209-18 PMID: 21263025
  3. RhoE binds to ROCK I and inhibits downstream signaling.
    Mol Cell Biol. 2003 Jun;23(12):4219-29 PMID: 12773565
  4. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.
    Nat Cell Biol. 2001 Apr;3(4):339-45 PMID: 11283606
  5. Blinded by the Light: The Growing Complexity of p53.
    Cell. 2009 May 1;137(3):413-31 PMID: 19410540
  6. The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter.
    Biochem Biophys Res Commun. 2011 Jun 3;409(2):211-6 PMID: 21565167
  7. Mutant p53 gain-of-function in cancer.
    Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a001107 PMID: 20182618
  8. Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.
    Nat Cell Biol. 2010 Apr;12(4):390-9 PMID: 20305651
  9. Transcriptional regulation of the small GTPase RhoB gene by TGF{beta}-induced signaling pathways.
    FASEB J. 2010 Mar;24(3):891-905 PMID: 19890017
  10. Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
    Int J Cancer. 2010 Aug 1;127(3):505-12 PMID: 20232393
  11. Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.
    Cancer Res. 2011 Feb 1;71(3):747-57 PMID: 21266354
  12. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis.
    Cell. 2009 Jun 12;137(6):1032-46 PMID: 19524507
  13. RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress.
    Curr Biol. 2006 Dec 19;16(24):2466-72 PMID: 17174923
  14. The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.
    PLoS One. 2011 Feb 23;6(2):e17108 PMID: 21373644
  15. A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage.
    PLoS One. 2008 May 28;3(5):e2254 PMID: 18509476
  16. Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.
    Genes Dev. 2007 Mar 1;21(5):562-77 PMID: 17344417
  17. p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival.
    Cell Res. 2011 Apr;21(4):666-82 PMID: 21079653
  18. Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells.
    Cancer Res. 2006 Jun 15;66(12):6319-26 PMID: 16778209
  19. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.
    Nature. 2010 Oct 21;467(7318):986-90 PMID: 20962848
  20. Transcriptional control of human p53-regulated genes.
    Nat Rev Mol Cell Biol. 2008 May;9(5):402-12 PMID: 18431400
  21. Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.
    J Cell Biol. 2005 Jan 17;168(2):245-55 PMID: 15657395
  22. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
    Nat Cell Biol. 2010 May;12(5):457-67 PMID: 20383141
  23. The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals.
    PLoS One. 2011 Feb 24;6(2):e17380 PMID: 21390328
  24. RHO-GTPases and cancer.
    Nat Rev Cancer. 2002 Feb;2(2):133-42 PMID: 12635176
  25. Rho GTPases: biochemistry and biology.
    Annu Rev Cell Dev Biol. 2005;21:247-69 PMID: 16212495
  26. Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB.
    Mol Cancer Res. 2010 May;8(5):691-700 PMID: 20460403
  27. Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices.
    J Cell Biol. 2007 Jul 2;178(1):23-30 PMID: 17606864
  28. Tumor suppressor p53 meets microRNAs.
    J Mol Cell Biol. 2011 Feb;3(1):44-50 PMID: 21278451
  29. p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control.
    Oncogene. 2010 May 13;29(19):2864-76 PMID: 20190821
  30. Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility.
    Nat Struct Mol Biol. 2007 Mar;14(3):215-23 PMID: 17310253
Article Info
Journal
Transcription
Abbr.
Transcription
ISSN
2154-1272
DOI
10.4161/trns.2.5.16904
Published
2011-00-00
Pages
211-5
Language
English
Region
United States
NLM ID
101530967
PMCID
PMC3265777
Subset
IM
Grants
Cancer Research UK · United Kingdom
External Links
PubMed source DOI: 10.4161/trns.2.5.16904 PMC Full Text View journal details
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