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PMID: 22220553 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Early progress in epigenetic regulation of endothelin pathway genes.

British journal of pharmacology ·Vol. 168 ·No. 2 ·2013-01-00 ·Pages 327-34

Welch AK, Jacobs ME, Wingo CS, Cain BD

Abstract

Control of gene transcription is a major regulatory determinant for function of the endothelin pathway. Epigenetic mechanisms act on tissue-specific gene expression during development and in response to physiological stimuli. Most of the limited evidence available on epigenetic regulation of the endothelin pathway focuses on the EDN1 and EDNRB genes. Examination of whole genome databases suggests that both genes are influenced by histone modifications and DNA methylation. This interpretation is supported by studies directed at detecting epigenetic action on the two genes. The clearest illustration of epigenetic factors altering endothelin signalling is DNA methylation-associated EDNRB silencing during tumourigenesis. This review summarizes our current understanding of epigenetic regulation of the endothelin pathway genes. LINKED ARTICLES This article is part of a themed section on Endothelin. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2013.168.issue-1.

MeSH Terms
Animals DNA Methylation Endothelins/genetics Epigenesis, Genetic Histones/metabolism Humans
Chemicals
Endothelins Histones
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Welch A K
Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Jacobs M E
Wingo C S
Cain B D
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
1476-5381
DOI
10.1111/j.1476-5381.2012.01826.x
Published
2013-01-00
Pages
327-34
Language
English
Region
England
NLM ID
7502536
PMCID
PMC3572559
Subset
IM
Grants
NIDDK NIH HHS · R01 DK082680 · United States
NIDDK NIH HHS · T32 DK076541 · United States
NIDDK NIH HHS · T32 DK 076541 · United States
NIDDK NIH HHS · R01 DK 82680 · United States
External Links
PubMed source DOI: 10.1111/j.1476-5381.2012.01826.x PMC Full Text View journal details
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