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PMID: 22123233 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

p53: exercise capacity and metabolism.

Current opinion in oncology ·Vol. 24 ·No. 1 ·2012-01-00 ·Pages 76-82

Wang PY, Zhuang J, Hwang PM

Abstract

There is an inverse relationship between cancer incidence and cardiorespiratory fitness in large population studies. Mechanistic insights into these observations may strengthen the rationale for encouraging exercise fitness in the clinics for cancer prevention and may promote the development of new preventive strategies. Studying the multifaceted activities of p53, a critical tumor suppressor gene, has revealed various cellular pathways necessary for adapting to environmental stresses. Genetic connections are being made between p53 and an increasing number of metabolic activities such as oxidative phosphorylation, glycolysis and fatty acid oxidation. In-vivo mouse models show that p53 plays an important role in determining both basal aerobic exercise capacity and its improvement by training. The genetic pathways by which p53 regulates metabolism and exercise may help explain significant epidemiologic observations connecting cardiorespiratory fitness and cancer. Further understanding of these molecular pathways through human translational studies may promote the development of new cancer preventive strategies.

MeSH Terms
Aerobiosis Anaerobiosis Animals Cell Respiration/physiology Exercise/physiology Humans Mice Mitochondria/metabolism,physiology Neoplasms/genetics,metabolism,prevention & control Tumor Suppressor Protein p53/genetics,metabolism
Chemicals
Tumor Suppressor Protein p53
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wang Ping-Yuan
Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Zhuang Jie
Hwang Paul M
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Article Info
Journal
Current opinion in oncology
Abbr.
Curr Opin Oncol
ISSN
1531-703X
DOI
10.1097/CCO.0b013e32834de1d8
Published
2012-01-00
Pages
76-82
Language
English
Region
United States
NLM ID
9007265
PMCID
PMC4153442
Subset
IM
Grants
Intramural NIH HHS · ZIA HL006051-03 · United States
External Links
PubMed source DOI: 10.1097/CCO.0b013e32834de1d8 PMC Full Text View journal details
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