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题目:: Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses.
作者:: Chang(Pheh-Ping),Barral(Patricia),Fitch(Jessica),Pratama(Alvin),Ma(Cindy S),Kallies(Axel),Hogan(Jennifer J),Cerundolo(Vincenzo),Tangye(Stuart G),Bittman(Robert),Nutt(Stephen L),Brink(Robert),Godfrey(Dale I),Batista(Facundo D),Vinuesa(Carola G)
状态:: 发布时间2011-12-19 , 更新时间 2016-11-22
期刊:: Nat Immunol
摘要:: Lipid antigens trigger help from natural killer T cells (NKT cells) for B cells, and direct conjugation of lipid agonists to antigen profoundly augments antibody responses. Here we show that in vivo, NKT cells engaged in stable and prolonged cognate interactions with B cells and induced the formation of early germinal centers. Mouse and human NKT cells formed CXCR5(+)PD-1(hi) follicular helper NKT cells (NKT(FH) cells), and this process required expression of the transcriptional repressor Bcl-6, signaling via the coreceptor CD28 and interaction with B cells. NKT(FH) cells provided direct cognate help to antigen-specific B cells that was dependent on interleukin 21 (IL-21). Unlike T cell-dependent germinal centers, those driven by NKT(FH) cells did not generate long-lived plasma cells. Our results demonstrate the existence of a Bcl-6-dependent subset of NKT cells specialized in providing help to B cells.
语言:: eng
DOI:: 10.1038/ni.2166

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