TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy.

Cell cycle (Georgetown, Tex.) ·Vol. 10 ·No. 23 ·2011-12-01 ·Pages 3987-8

Peña-Llopis S, Brugarolas J

Abstract

暂无摘要

MeSH Terms

Autophagy Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics,metabolism Cell Cycle Endocytosis Gene Expression Regulation Humans Lysosomes/metabolism,physiology Mechanistic Target of Rapamycin Complex 1 Multiprotein Complexes Phosphorylation Protein Transport Proteins/genetics,metabolism Sirolimus/pharmacology TOR Serine-Threonine Kinases Vacuolar Proton-Translocating ATPases/genetics,metabolism

Chemicals

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Multiprotein Complexes Proteins TFEB protein, human Mechanistic Target of Rapamycin Complex 1 TOR Serine-Threonine Kinases Vacuolar Proton-Translocating ATPases Sirolimus

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Peña-Llopis Samuel

Brugarolas James

References (11)

11 references, click to expand

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Transcriptional activation of lysosomal exocytosis promotes cellular clearance.
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Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.
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Regulation of TFEB and V-ATPases by mTORC1.
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Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake.
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mTOR: from growth signal integration to cancer, diabetes and ageing.
Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35 PMID: 21157483
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.
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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.
Nat Med. 2004 Jun;10(6):594-601 PMID: 15156201
Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
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Termination of autophagy and reformation of lysosomes regulated by mTOR.
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Article Info

Journal

Cell cycle (Georgetown, Tex.)

Abbr.

Cell Cycle

ISSN

1551-4005

DOI

10.4161/cc.10.23.18251

Published

2011-12-01

Epub

2011-00-01

Pages

3987-8

Language

English

Region

United States

NLM ID

101137841

PMCID

PMC3272281

Subset

External Links

PubMed source DOI: 10.4161/cc.10.23.18251 PMC Full Text View journal details

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TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy.

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