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PMID: 22076845 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A late-stage intermediate in salinomycin biosynthesis is revealed by specific mutation in the biosynthetic gene cluster.

Chembiochem : a European journal of chemical biology ·Vol. 13 ·No. 1 ·2012-01-02 ·Pages 66-71

Yurkovich ME, Tyrakis PA, Hong H, Sun Y, Samborskyy M, Kamiya K, Leadlay PF

Abstract

暂无摘要

MeSH Terms

Biosynthetic Pathways/genetics Genomic Library Molecular Conformation Mutation Polyketide Synthases/genetics,metabolism Pyrans/chemistry,metabolism Streptomyces/enzymology,genetics,metabolism

Chemicals

Pyrans salinomycin Polyketide Synthases

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Yurkovich Marie E

Department of Biochemistry, University of Cambridge, Cambridge, UK.

Tyrakis Petros A

Hong Hui

Sun Yuhui

Samborskyy Markiyan

Kamiya Kohei

Leadlay Peter F

Article Info

Journal

Chembiochem : a European journal of chemical biology

Abbr.

Chembiochem

ISSN

1439-7633

DOI

10.1002/cbic.201100590

Published

2012-01-02

Epub

2011-00-11

Pages

66-71

Language

English

Region

Germany

NLM ID

100937360

Subset

Grants

Biotechnology and Biological Sciences Research Council · BB/D018943/1 · United Kingdom

Biotechnology and Biological Sciences Research Council · BB/I002413/1 · United Kingdom

External Links

PubMed source DOI: 10.1002/cbic.201100590 View journal details

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A late-stage intermediate in salinomycin biosynthesis is revealed by specific mutation in the biosynthetic gene cluster.

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