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题目:: Messenger RNA expression and genetic polymorphisms of cell cycle control genes and chromosomal aberrations in Chinese vinyl chloride monomer-exposed workers.
作者:: Qiu(Yu-lan),Qiu(Yu-Lan),Sun(Pin),Wang(Wei),Wang(Tong),Xia(Zhao-Lin)
状态:: 发布时间2011-12-14 , 更新时间 2016-10-18
期刊:: J Occup Environ Med
摘要:: To evaluate the expressions of p53, p21, and CCND1 in the peripheral blood lymphocytes of vinyl chloride monomer (VCM)-exposed workers and potential relationships with their exposures, polymorphisms, and chromosomal aberrations.,The study was performed on 77 occupationally VCM-exposed workers and 43 unexposed controls. The quantities of mRNA expression of p53, p21, and CCND1 genes were detected by real-time polymerase chain reaction.,p53 mRNA expression of VCM-low- and high-exposure groups was significantly lower than that of nonexposed group (P < 0.001), but p21 mRNA expression of the two VCM-exposed groups was significantly higher than that of the nonexposed group (P < 0.001). This study did not find the relationship between chromosomal aberrations, genotypes, and the expression of p53, p21, and CCND1.,Messenger RNA expressions of p53 and p21 are changed with VCM-exposure status.
语言:: eng
DOI:: 10.1097/JOM.0b013e3182363bfb

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