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PMID: 22069745 Published · ppublish English Journal Article Review

G(i/o) protein-dependent and -independent actions of Pertussis Toxin (PTX).

Toxins ·Vol. 3 ·No. 7 ·2011-00-00 ·Pages 884-99

Mangmool S, Kurose H

Abstract

Pertussis toxin (PTX) is a typical A-B toxin. The A-protomer (S1 subunit) exhibits ADP-ribosyltransferase activity. The B-oligomer consists of four subunits (S2 to S5) and binds extracellular molecules that allow the toxin to enter the cells. The A-protomer ADP-ribosylates the α subunits of heterotrimeric G(i/o) proteins, resulting in the receptors being uncoupled from the G(i/o) proteins. The B-oligomer binds proteins expressed on the cell surface, such as Toll-like receptor 4, and activates an intracellular signal transduction cascade. Thus, PTX modifies cellular responses by at least two different signaling pathways; ADP-ribosylation of the Gα(i/o) proteins by the A-protomer (G(i/o) protein-dependent action) and the interaction of the B-oligomer with cell surface proteins (G(i/o) protein-independent action).

Keywords
A-protomer ADP-ribosylation B-oligomer G protein-coupled receptor Gi/o-dependent Gi/o-independent Toll-like receptor 4 heterotrimeric G protein pertussis toxin
MeSH Terms
ADP Ribose Transferases/genetics,metabolism ADP-Ribosylation Factors/genetics,metabolism Animals GTP-Binding Protein alpha Subunits, Gi-Go/genetics,metabolism Humans Membrane Proteins/genetics,metabolism Pertussis Toxin/chemistry,pharmacology Promoter Regions, Genetic Signal Transduction Toll-Like Receptor 4/genetics,metabolism
Chemicals
Membrane Proteins Toll-Like Receptor 4 ADP Ribose Transferases Pertussis Toxin GTP-Binding Protein alpha Subunits, Gi-Go ADP-Ribosylation Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mangmool Supachoke
Department of Pharmacology, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhaya, Rajathevi, Bangkok, Thailand. pysmm@mahidol.ac.th
Kurose Hitoshi
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Article Info
Journal
Toxins
Abbr.
Toxins (Basel)
ISSN
2072-6651
DOI
10.3390/toxins3070884
Email
pysmm@mahidol.ac.th
Published
2011-00-00
Epub
2011-00-15
Pages
884-99
Language
English
Region
Switzerland
NLM ID
101530765
PMCID
PMC3202852
Subset
IM
External Links
PubMed source DOI: 10.3390/toxins3070884 PMC Full Text View journal details
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