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PMID: 22055570 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Plasticity in mast cell responses during bacterial infections.

Current opinion in microbiology ·Vol. 15 ·No. 1 ·2012-02-00 ·Pages 78-84

Chan CY, St John AL, Abraham SN

Abstract

Mast cells (MCs) have been implicated in orchestrating the host's early innate immune and adaptive immune responses in several models of acute bacterial infections. Most of this activity results in early clearance of the bacteria and timely resolution of infection. However, during chronic infections because of the prolonged nature of MC-bacterial interactions, the role of the MC in determining the fate of infection is markedly more complex. Depending on the nature of the pathogen, severity of infection, and its association with a preexisting inflammatory disease, MCs may promote rather than contain chronic infections and exacerbate their pathological sequellae.

MeSH Terms
Animals Bacteria/immunology,pathogenicity Bacterial Infections/immunology,pathology Humans Mast Cells/immunology,microbiology Mice Models, Biological
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chan Cheryl Y
Department of Pathology, Duke University Medical Center, Durham, NC, USA.
St John Ashley L
Abraham Soman N
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Article Info
Journal
Current opinion in microbiology
Abbr.
Curr Opin Microbiol
ISSN
1879-0364
DOI
10.1016/j.mib.2011.10.007
Published
2012-02-00
Epub
2011-00-04
Pages
78-84
Language
English
Region
England
NLM ID
9815056
PMCID
PMC4476652
Subset
IM
Grants
NIDDK NIH HHS · R37 DK050814 · United States
PHS HHS · R01 A135678 · United States
PHS HHS · R01 A150021 · United States
NIAID NIH HHS · R01 AI050021 · United States
NIDDK NIH HHS · R37 DK50814 · United States
NIDDK NIH HHS · R01 DK077159 · United States
PHS HHS · R21 A1056101 · United States
NIAID NIH HHS · R01 AI096305 · United States
External Links
PubMed source DOI: 10.1016/j.mib.2011.10.007 PMC Full Text View journal details
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