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PMID: 22035838 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Cell death in the maintenance and abrogation of tolerance: the five Ws of dying cells.

Immunity ·Vol. 35 ·No. 4 ·2011-10-28 ·Pages 456-66

Griffith TS, Ferguson TA

Abstract

The mammalian immune system continually faces death in the form of its own dead and dying cells that arise during normal tissue turnover, infections, cellular damage, and cancer. Complex decisions must then be made that will permit a protective response to pathogens, while at the same time destroying tumors but not attacking vital systems of the host that could lead to autoimmunity. By using an investigative technique termed the five Ws (who, what, when, where, and why), we will examine how the immune system responds to antigens generated via cell death. This analysis will give us a better understanding of the molecular differences fundamental to tolerogenic or immunogenic cell death, the cells that sense and react to the dead cells, and the consequences of these fundamental elements on the maintenance or abrogation of tolerance.

MeSH Terms
Animals Autoimmunity Cell Death Dendritic Cells/immunology Humans Immune Tolerance Lymphocyte Activation T-Lymphocytes/immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Griffith Thomas S
Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA. tgriffit@umn.edu
Ferguson Thomas A
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Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1097-4180
DOI
10.1016/j.immuni.2011.08.011
Email
tgriffit@umn.edu
Published
2011-10-28
Pages
456-66
Language
English
Region
United States
NLM ID
9432918
PMCID
PMC3205359
Subset
IM
Grants
NEI NIH HHS · F32 EY006765 · United States
NCI NIH HHS · CA109446 · United States
NIAID NIH HHS · R01 AI077565-01A1 · United States
NEI NIH HHS · R01 EY006765-25 · United States
NIAID NIH HHS · R56 AI077565 · United States
NCI NIH HHS · R01 CA109446 · United States
NEI NIH HHS · R01 EY015570-07 · United States
NEI NIH HHS · P30 EY002687 · United States
NEI NIH HHS · R01 EY015570 · United States
NCI NIH HHS · R01 CA109446-09 · United States
NEI NIH HHS · R01 EY006765 · United States
NEI NIH HHS · EY015570 · United States
NEI NIH HHS · EY06765 · United States
NEI NIH HHS · EY02687 · United States
NIAID NIH HHS · AI077565 · United States
External Links
PubMed source DOI: 10.1016/j.immuni.2011.08.011 PMC Full Text View journal details
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