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PMID: 2201927 Published · ppublish English Journal Article Review

Molecular pharmacology of protein kinases.

Neurochemical research ·Vol. 15 ·No. 4 ·1990-04-00 ·Pages 431-4

Hidaka H, Hagiwara M, Chijiwa T

Abstract

暂无摘要

MeSH Terms
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Animals Enzyme Activation/drug effects Isoquinolines/pharmacology Piperazines/pharmacology Protein Kinase Inhibitors Protein Kinases/metabolism Sulfonamides/pharmacology
Chemicals
Isoquinolines Piperazines Protein Kinase Inhibitors Sulfonamides W 7 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Protein Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hidaka H
Department of Pharmacology, Nagoya University School of Medicine, Japan.
Hagiwara M
Chijiwa T
References (19)
19 references, click to expand
  1. Inhibitory effects of aminoglycosides on renal protein phosphorylation by protein kinase C.
    J Pharmacol Exp Ther. 1988 Jan;244(1):355-60 PMID: 3336010
  2. Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases.
    Biochem Pharmacol. 1988 Aug 1;37(15):2987-92 PMID: 3164998
  3. Relationships between calcium and cyclic nucleotides in cell activation.
    Physiol Rev. 1977 Jul;57(3):421-509 PMID: 196302
  4. Tissue-specific expression of three distinct types of rabbit protein kinase C.
    Nature. 1987 Jan 8-14;325(7000):161-6 PMID: 3808073
  5. Selective binding of L-thyroxine by myosin light chain kinase.
    J Biol Chem. 1989 Jan 5;264(1):40-4 PMID: 2909527
  6. N-(2-Aminoethyl)-5-isoquinolinesulfonamide, a newly synthesized protein kinase inhibitor, functions as a ligand in affinity chromatography. Purification of Ca2+-activated, phospholipid-dependent and other protein kinases.
    J Biol Chem. 1985 Mar 10;260(5):2922-5 PMID: 2982842
  7. Modulation of tyrosine phosphorylation of p36 and other substrates by the S-100 protein.
    J Biol Chem. 1988 May 5;263(13):6438-41 PMID: 2834378
  8. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
    Biochemistry. 1984 Oct 9;23 (21):5036-41 PMID: 6238627
  9. A fluorescent protein kinase C inhibitor: 1-(1-hydroxy-5-isoquinolinylsulfonyl)piperazine.
    Pharmacology. 1988;36(6):365-70 PMID: 3420158
  10. Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase.
    Mol Pharmacol. 1987 May;31(5):523-8 PMID: 3574296
  11. Cell type-specific expression of protein kinase C isozymes in the rabbit cerebellum.
    J Biol Chem. 1988 Apr 5;263(10):4523-6 PMID: 3280565
  12. KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
    J Biol Chem. 1990 Mar 15;265(8):4315-20 PMID: 2155222
  13. Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.
    J Biol Chem. 1987 Jun 5;262(16):7796-801 PMID: 3108259
  14. An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle.
    J Biol Chem. 1968 Jul 10;243(13):3763-5 PMID: 4298072
  15. A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis.
    J Biol Chem. 1989 Mar 25;264(9):4924-7 PMID: 2925675
  16. An inhibitor of protein kinase C, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine(H-7) inhibits TPA-induced reduction of vincristine uptake from P388 murine leukemic cell.
    Leuk Res. 1986;10(9):1063-9 PMID: 3762216
  17. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives.
    Mol Pharmacol. 1987 Jul;32(1):7-12 PMID: 2955213
  18. Relaxation of vascular smooth muscle by HA-1004, an inhibitor of cyclic nucleotide-dependent protein kinase.
    J Pharmacol Exp Ther. 1985 Nov;235(2):495-9 PMID: 2997436
  19. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.
    J Biol Chem. 1990 Mar 25;265(9):5267-72 PMID: 2156866
Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1007/BF00969929
Published
1990-04-00
Pages
431-4
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00969929 View journal details
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