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PMID: 21989406 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

ExoCarta 2012: database of exosomal proteins, RNA and lipids.

Nucleic acids research ·Vol. 40 ·No. Database issue ·2012-01-00 ·Pages D1241-4

Mathivanan S, Fahner CJ, Reid GE, Simpson RJ

Abstract

Exosomes are membraneous nanovesicles of endocytic origin released by most cell types from diverse organisms; they play a critical role in cell-cell communication. ExoCarta (http://www.exocarta.org) is a manually curated database of exosomal proteins, RNA and lipids. The database catalogs information from both published and unpublished exosomal studies. The mode of exosomal purification and characterization, the biophysical and molecular properties are listed in the database aiding biomedical scientists in assessing the quality of the exosomal preparation and the corresponding data obtained. Currently, ExoCarta (Version 3.1) contains information on 11,261 protein entries, 2375 mRNA entries and 764 miRNA entries that were obtained from 134 exosomal studies. In addition to the data update, as a new feature, lipids identified in exosomes are added to ExoCarta. We believe that this free web-based community resource will aid researchers in identifying molecular signatures (proteins/RNA/lipids) that are specific to certain tissue/cell type derived exosomes and trigger new exosomal studies.

MeSH Terms

Cell Fractionation Databases, Genetic Exosomes/chemistry Lipids/analysis MicroRNAs/analysis Proteins/analysis RNA/analysis RNA, Messenger/analysis

Chemicals

Lipids MicroRNAs Proteins RNA, Messenger RNA

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Mathivanan Suresh

Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia. Richard.Simpson@latrobe.edu.au

Fahner Cassie J

Reid Gavin E

Simpson Richard J

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

1362-4962

DOI

10.1093/nar/gkr828

richard.simpson@latrobe.edu.au

Published

2012-01-00

Epub

2011-00-11

Pages

D1241-4

Language

English

Region

England

NLM ID

0411011

PMCID

PMC3245025

Subset

External Links

PubMed source DOI: 10.1093/nar/gkr828 PMC Full Text View journal details

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