| GeneLibs

题目:: Targeting heat shock response pathways to treat pancreatic cancer.
作者:: Xia(Yi),Rocchi(Palma),Iovanna(Juan L),Peng(Ling)
状态:: 发布时间2012-01-16 , 更新时间 2012-01-16
期刊:: Drug Discov Today
摘要:: Pancreatic cancer belongs to the group of extremely aggressive human cancers; conventional cancer treatments have little impact. Increasing understanding of the pathways associated with pancreatic cancer progression has enabled the development of targeted therapy on this cancer. Heat shock proteins (HSPs) and related heat shock response (HSR) pathways control multiple important oncogenic pathways for pancreatic cancer development. Consequently, they represent promising novel targets for pancreatic cancer therapy. Various strategies have been proposed and elaborated to target HSPs/HSR in pancreatic cancer with the corresponding modulators, the details of which are highlighted in this review.
语言:: eng
DOI:: 10.1016/j.drudis.2011.09.016

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