Home LiteratureArticle Details
PMID: 21984761 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Knime4Bio: a set of custom nodes for the interpretation of next-generation sequencing data with KNIME.

Bioinformatics (Oxford, England) ·Vol. 27 ·No. 22 ·2011-11-15 ·Pages 3200-1

Lindenbaum P, Le Scouarnec S, Portero V, Redon R

Abstract

Analysing large amounts of data generated by next-generation sequencing (NGS) technologies is difficult for researchers or clinicians without computational skills. They are often compelled to delegate this task to computer biologists working with command line utilities. The availability of easy-to-use tools will become essential with the generalization of NGS in research and diagnosis. It will enable investigators to handle much more of the analysis. Here, we describe Knime4Bio, a set of custom nodes for the KNIME (The Konstanz Information Miner) interactive graphical workbench, for the interpretation of large biological datasets. We demonstrate that this tool can be utilized to quickly retrieve previously published scientific findings.

MeSH Terms
Hajdu-Cheney Syndrome/genetics High-Throughput Nucleotide Sequencing/methods Humans Software
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lindenbaum Pierre
Institut du thorax, Inserm UMR 915, Centre Hospitalier Universitaire de Nantes, 44000 Nantes, France.
Le Scouarnec Solena
Portero Vincent
Redon Richard
References (17)
17 references, click to expand
  1. BigWig and BigBed: enabling browsing of large distributed datasets.
    Bioinformatics. 2010 Sep 1;26(17):2204-7 PMID: 20639541
  2. The UCSC Known Genes.
    Bioinformatics. 2006 May 1;22(9):1036-46 PMID: 16500937
  3. Integrating diverse databases into an unified analysis framework: a Galaxy approach.
    Database (Oxford). 2011 Apr 29;2011:bar011 PMID: 21531983
  4. Taverna: a tool for building and running workflows of services.
    Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W729-32 PMID: 16845108
  5. Extending KNIME for next-generation sequencing data analysis.
    Bioinformatics. 2011 Oct 15;27(20):2907-9 PMID: 21873641
  6. Tabix: fast retrieval of sequence features from generic TAB-delimited files.
    Bioinformatics. 2011 Mar 1;27(5):718-9 PMID: 21208982
  7. The variant call format and VCFtools.
    Bioinformatics. 2011 Aug 1;27(15):2156-8 PMID: 21653522
  8. Predicting deleterious amino acid substitutions.
    Genome Res. 2001 May;11(5):863-74 PMID: 11337480
  9. The Sequence Alignment/Map format and SAMtools.
    Bioinformatics. 2009 Aug 15;25(16):2078-9 PMID: 19505943
  10. Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis.
    Nat Genet. 2011 Mar 06;43(4):306-8 PMID: 21378989
  11. Fast and accurate long-read alignment with Burrows-Wheeler transform.
    Bioinformatics. 2010 Mar 1;26(5):589-95 PMID: 20080505
  12. High-throughput bioinformatics with the Cyrille2 pipeline system.
    BMC Bioinformatics. 2008 Feb 12;9:96 PMID: 18269742
  13. dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions.
    Hum Mutat. 2011 Aug;32(8):894-9 PMID: 21520341
  14. A method and server for predicting damaging missense mutations.
    Nat Methods. 2010 Apr;7(4):248-9 PMID: 20354512
  15. Integrative genomics viewer.
    Nat Biotechnol. 2011 Jan;29(1):24-6 PMID: 21221095
  16. Mobyle: a new full web bioinformatics framework.
    Bioinformatics. 2009 Nov 15;25(22):3005-11 PMID: 19689959
  17. STRING 7--recent developments in the integration and prediction of protein interactions.
    Nucleic Acids Res. 2007 Jan;35(Database issue):D358-62 PMID: 17098935
Article Info
Journal
Bioinformatics (Oxford, England)
Abbr.
Bioinformatics
ISSN
1367-4811
Published
2011-11-15
Epub
2011-00-07
Pages
3200-1
Language
English
Region
England
NLM ID
9808944
PMCID
PMC3208396
Subset
IM
Grants
Wellcome Trust · WT077008 · United Kingdom
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com