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PMID: 21941275 Published · epublish English Journal Article Review

Proteins on the move: insights gained from fluorescent protein technologies.

Nature reviews. Molecular cell biology ·Vol. 12 ·No. 10 ·2011-09-23 ·Pages 656-68

Miyawaki A

Abstract

Proteins are always on the move, and this may occur through diffusion or active transport. The realization that the regulation of signal transduction is highly dynamic in space and time has stimulated intense interest in the movement of proteins. Over the past decade, numerous new technologies using fluorescent proteins have been developed, allowing us to observe the spatiotemporal dynamics of proteins in living cells. These technologies have greatly advanced our understanding of protein dynamics, including protein movement and protein interactions.

MeSH Terms
Animals Biotechnology/methods Green Fluorescent Proteins/genetics,metabolism Humans Luminescent Proteins/genetics,metabolism Protein Binding Proteins Signal Transduction/genetics,physiology
Chemicals
Luminescent Proteins Proteins Green Fluorescent Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Miyawaki Atsushi
Life Function and Dynamics, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Saitama, Japan. matsushi@brain.riken.jp
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm3199
Email
matsushi@brain.riken.jp
Published
2011-09-23
Epub
2011-00-23
Pages
656-68
Language
English
Region
England
NLM ID
100962782
Subset
IM
External Links
PubMed source DOI: 10.1038/nrm3199 View journal details
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