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PMID: 21927634 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Cell entry of enveloped viruses.

Current opinion in virology ·Vol. 1 ·No. 2 ·2011-08-00 ·Pages 92-100

Plemper RK

Abstract

Infection of cells by enveloped viruses requires merger of the viral envelope membrane with target cell membranes, resulting in the formation of fusion pores through which the viral genome is released. Since lipid membranes do not mix spontaneously, the fusion process is energy-dependent and mediated by viral envelope glycoprotein complexes. Based on their structural and mechanistic properties, three distinct classes of viral fusion proteins have been identified to date. Despite their diversity, basic principles of viral membrane fusion, simultaneous engagement of both donor and target membrane and refolding into hairpin-like structures, have emerged as universally conserved. This article provides an overview of the basic principles of viral membrane fusion common to all enveloped viruses and discusses the specific structural and functional features of the different fusion protein classes by example of the paramyxovirus, flavivirus and rhabdovirus families.

MeSH Terms
Animals Humans Viral Envelope Proteins/chemistry,genetics,metabolism Virus Diseases/virology Virus Internalization Virus Physiological Phenomena Viruses/chemistry,genetics,metabolism
Chemicals
Viral Envelope Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Plemper Richard K
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. rplempe@emory.edu
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Article Info
Journal
Current opinion in virology
Abbr.
Curr Opin Virol
ISSN
1879-6265
DOI
10.1016/j.coviro.2011.06.002
Email
rplempe@emory.edu
Published
2011-08-00
Pages
92-100
Language
English
Region
Netherlands
NLM ID
101560941
PMCID
PMC3171968
Subset
IM
Grants
NIAID NIH HHS · R56 AI083402 · United States
NIAID NIH HHS · R01 AI071002 · United States
NIAID NIH HHS · R01 AI083402 · United States
NIAID NIH HHS · R01 AI071002-05 · United States
NIAID NIH HHS · R56 AI083402-01A1 · United States
NIAID NIH HHS · R01 AI083402-01A2 · United States
NIAID NIH HHS · AI083402 · United States
NIAID NIH HHS · AI071002 · United States
External Links
PubMed source DOI: 10.1016/j.coviro.2011.06.002 PMC Full Text View journal details
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