Breaking the cell cycle of HSCs by p57 and friends.
作者:
Tesio(Melania),Trumpp(Andreas)
状态:
发布时间2011-09-02
, 更新时间 2016-05-18
期刊:
Cell Stem Cell
摘要:
The cell cycle regulators involved in maintaining the quiescence, and thereby the self-renewal capacity, of somatic stem cells have long been elusive. Two new Cell Stem Cell articles in this issue (Matsumoto et al., 2011; Zou et al., 2011) now show that the CDK inhibitor p57 is a crucial brake for cycling HSCs, and links self-renewal activity to cell cycle quiescence.