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PMID: 21881557 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases.

Kidney international ·Vol. 80 ·No. 11 ·2011-12-00 ·Pages 1138-45

van Balkom BW, Pisitkun T, Verhaar MC, Knepper MA

Abstract

Exosomes are 40-100 nm membrane vesicles secreted into the extracellular space by numerous cell types. These structures can be isolated from body fluids including urine and plasma. Exosomes contain proteins, mRNAs, miRNAs, and signaling molecules that reflect the physiological state of their cells of origin and consequently provide a rich source of potential biomarker molecules. Aside from diagnostic uses, exosome-mediated transfer of proteins, mRNAs, miRNAs, and signaling molecules offer the promise that they may be used for therapeutic purposes. In this review, we integrate new knowledge about exosomes from outside the field of nephrology with recent progress by renal researchers in order to provide a basis for speculation about how the study of exosomes may affect the fields of nephrology and renal physiology in the next few years.

MeSH Terms
Drug Carriers Exosomes/chemistry,transplantation Forecasting Humans Kidney Diseases/diagnosis,therapy Proteins RNA
Chemicals
Drug Carriers Proteins RNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
van Balkom Bas W M
Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Pisitkun Trairak
Verhaar Marianne C
Knepper Mark A
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Article Info
Journal
Kidney international
Abbr.
Kidney Int
ISSN
1523-1755
DOI
10.1038/ki.2011.292
Published
2011-12-00
Epub
2011-00-31
Pages
1138-45
Language
English
Region
United States
NLM ID
0323470
PMCID
PMC3412193
Subset
IM
Grants
Intramural NIH HHS · Z01 HL001285-22 · United States
Intramural NIH HHS · ZIA HL001285-23 · United States
Intramural NIH HHS · Z99 HL999999 · United States
NHLBI NIH HHS · Z01-HL-001285 · United States
Intramural NIH HHS · Z01 HL001285-21 · United States
Intramural NIH HHS · Z01 HL001285 · United States
Intramural NIH HHS · ZIA HL001285-24 · United States
External Links
PubMed source DOI: 10.1038/ki.2011.292 PMC Full Text View journal details
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