Home LiteratureArticle Details
PMID: 21876726 Published · ppublish English Journal Article

Exosomes: secreted vesicles and intercellular communications.

F1000 biology reports ·Vol. 3 ·2011-00-00 ·Pages 15

Théry C

Abstract

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types, and are thought to play important roles in intercellular communications. Although exosomes were originally described in 1983, interest in these vesicles has really increased dramatically in the last 3 years, after the finding that they contain mRNA and microRNA. This discovery sparked renewed interest for the general field of membrane vesicles involved in intercellular communications, and research on these structures has grown exponentially over the last few years, probing their composition and function, as well as their potential value as biomarkers.

Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Théry Clotilde
Institut Curie INSERM U932, Paris France.
References (36)
36 references, click to expand
  1. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
    Nat Cell Biol. 2008 Dec;10(12):1470-6 PMID: 19011622
  2. Rab27a and Rab27b control different steps of the exosome secretion pathway.
    Nat Cell Biol. 2010 Jan;12(1):19-30; sup pp 1-13 PMID: 19966785
  3. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes.
    Nat Med. 1998 May;4(5):594-600 PMID: 9585234
  4. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.
    J Cell Biol. 2010 Apr 19;189(2):223-32 PMID: 20404108
  5. Ectosomes released by human neutrophils are specialized functional units.
    J Immunol. 1999 Oct 15;163(8):4564-73 PMID: 10510400
  6. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes.
    J Cell Biol. 1983 Aug;97(2):329-39 PMID: 6309857
  7. Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
    J Immunol. 2005 Aug 15;175(4):2237-43 PMID: 16081791
  8. The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles.
    Stem Cell Rev. 2008 Sep;4(3):137-47 PMID: 18665337
  9. Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes.
    Nat Immunol. 2002 Dec;3(12):1156-62 PMID: 12426563
  10. Alzheimer's disease beta-amyloid peptides are released in association with exosomes.
    Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11172-7 PMID: 16837572
  11. Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner.
    Traffic. 2005 Feb;6(2):131-43 PMID: 15634213
  12. Cells release prions in association with exosomes.
    Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9683-8 PMID: 15210972
  13. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming.
    Nat Med. 2001 Mar;7(3):297-303 PMID: 11231627
  14. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.
    Stem Cell Res. 2010 May;4(3):214-22 PMID: 20138817
  15. Ceramide triggers budding of exosome vesicles into multivesicular endosomes.
    Science. 2008 Feb 29;319(5867):1244-7 PMID: 18309083
  16. Modulation of vesicle shedding in 8701 BC human breast carcinoma cells.
    J Submicrosc Cytol Pathol. 1998 Jan;30(1):45-53 PMID: 9530851
  17. Exosomes: immune properties and potential clinical implementations.
    Semin Immunopathol. 2011 Sep;33(5):419-40 PMID: 21174094
  18. ExoCarta: A compendium of exosomal proteins and RNA.
    Proteomics. 2009 Nov;9(21):4997-5000 PMID: 19810033
  19. "Tolerosomes" are produced by intestinal epithelial cells.
    Eur J Immunol. 2001 Oct;31(10):2892-900 PMID: 11592064
  20. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.
    J Exp Med. 2002 May 20;195(10):1303-16 PMID: 12021310
  21. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes).
    J Biol Chem. 1987 Jul 5;262(19):9412-20 PMID: 3597417
  22. Microenvironmental pH is a key factor for exosome traffic in tumor cells.
    J Biol Chem. 2009 Dec 4;284(49):34211-22 PMID: 19801663
  23. Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes.
    Cancer Immunol Immunother. 2006 Jul;55(7):808-18 PMID: 16283305
  24. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.
    J Cell Biol. 1985 Sep;101(3):942-8 PMID: 2993317
  25. Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
    Proteomics Clin Appl. 2007 Nov;1(11):1446-61 PMID: 21136642
  26. Exosomes as a tumor immune escape mechanism: possible therapeutic implications.
    J Transl Med. 2008 Jul 22;6:37 PMID: 18644158
  27. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
    Nat Cell Biol. 2007 Jun;9(6):654-9 PMID: 17486113
  28. The prostasome: its secretion and function in man.
    Biochim Biophys Acta. 1985 Sep 9;822(2):203-18 PMID: 2992593
  29. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery.
    Leukemia. 2006 May;20(5):847-56 PMID: 16453000
  30. Membrane vesicles as conveyors of immune responses.
    Nat Rev Immunol. 2009 Aug;9(8):581-93 PMID: 19498381
  31. Cell biology: The ins and outs of exosomes.
    Science. 2005 Jun 24;308(5730):1862-3 PMID: 15976285
  32. Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity.
    Mol Cell Neurosci. 2011 Feb;46(2):409-18 PMID: 21111824
  33. B lymphocytes secrete antigen-presenting vesicles.
    J Exp Med. 1996 Mar 1;183(3):1161-72 PMID: 8642258
  34. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.
    J Cell Biol. 1999 Nov 1;147(3):599-610 PMID: 10545503
  35. Ectocytosis caused by sublytic autologous complement attack on human neutrophils. The sorting of endogenous plasma-membrane proteins and lipids into shed vesicles.
    Biochem J. 1991 Mar 1;274 ( Pt 2):381-6 PMID: 1848755
  36. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles.
    J Immunol. 2001 Jun 15;166(12):7309-18 PMID: 11390481
Article Info
Journal
F1000 biology reports
Abbr.
F1000 Biol Rep
ISSN
1757-594X
DOI
10.3410/B3-15
Published
2011-00-00
Epub
2011-00-01
Pages
15
Language
English
Region
England
NLM ID
101506835
PMCID
PMC3155154
External Links
PubMed source DOI: 10.3410/B3-15 PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2