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PMID: 2186664 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Developmental cell death: morphological diversity and multiple mechanisms.

Anatomy and embryology ·Vol. 181 ·No. 3 ·1990-00-00 ·Pages 195-213

Clarke PG

Abstract

Physiological cell death is a widespread phenomenon in the development of both vertebrates and invertebrates. This review concentrates on an aspect of developmental cell death that has tended to be neglected, the manner in which the cells are dismantled. It is emphasized that the dying cells may adopt one of at least three different morphological types: "apoptotic", "autophagic", and "non-lysosomal vesiculate". These probably reflect a corresponding multiplicity of intracellular events. In particular, the destruction of the cytoplasm in these three types appears to be achieved primarily by heterophagy, by autophagy and by non-lysosomal degradation, respectively. The various mechanisms underlying both nuclear and cytoplasmic destruction are reviewed in detail. The multiplicity of destructive mechanisms needs to be born in mind in studies of other aspects of cell death such as the signals which trigger it, since different signals probably trigger different types of cell death.

MeSH Terms
Animals Autophagy Cell Survival Chick Embryo Necrosis Phagocytosis Rats
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Clarke P G
Institut d'Anatomie, Lausanne, Switzerland.
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Article Info
Journal
Anatomy and embryology
Abbr.
Anat Embryol (Berl)
ISSN
0340-2061
DOI
10.1007/BF00174615
Published
1990-00-00
Pages
195-213
Language
English
Region
Germany
NLM ID
7505194
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00174615
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