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PMID: 2186180 Published · ppublish English Journal Article

The carboxy terminus of human immunodeficiency virus type 1 gp160 limits its proteolytic processing and transport in transfected cell lines.

Journal of virology ·Vol. 64 ·No. 6 ·1990-06-00 ·Pages 3100-3

Haffar OK, Nakamura GR, Berman PW

Abstract

Mutagenesis of the transmembrane domain and cytoplasmic tail of human immunodeficiency virus type 1 envelope glycoprotein gp160 revealed that its intracellular transport and processing in transfected cell lines were modulated by a functional domain included in the carboxy-terminal sequence consisting of residues 751 to 856.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cell Line Chimera Electrophoresis, Polyacrylamide Gel Gene Products, env/genetics,isolation & purification,metabolism Glycoproteins/genetics Glycoside Hydrolases HIV Envelope Protein gp160 HIV-1/genetics,metabolism Molecular Sequence Data Molecular Weight Mutation Protein Precursors/genetics,isolation & purification,metabolism Protein Processing, Post-Translational Transfection Viral Envelope Proteins/isolation & purification
Chemicals
Gene Products, env Glycoproteins HIV Envelope Protein gp160 Protein Precursors Viral Envelope Proteins Glycoside Hydrolases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Haffar O K
Department of Developmental Biology, Genetech Inc., South San Francisco, California 94080.
Nakamura G R
Berman P W
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.64.6.3100-3103.1990
Published
1990-06-00
Pages
3100-3
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC249502
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.64.6.3100-3103.1990 PMC Full Text View journal details
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