Cellular mechanism for ischemic ventricular arrhythmias.

Annual review of medicine ·Vol. 41 ·1990-00-00 ·Pages 231-8

Opie LH, Clusin WT

Abstract

Two of the major ionic abnormalities found early in ischemia are (a) loss of potassium with an increase in the extracellular potassium ion concentration and (b) an increase in free cytosolic calcium. Both of these ionic abnormalities can powerfully predispose to the development of arrhythmias.

MeSH Terms

Action Potentials/physiology Animals Arrhythmias, Cardiac/etiology,metabolism,physiopathology Calcium/metabolism Coronary Disease/complications,metabolism,physiopathology Heart Ventricles Humans Myocardium/metabolism Potassium/metabolism

Chemicals

Potassium Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Opie L H

Medical Research Council/University of Cape Town Ischemic Heart Disease Research Unit, University of Cape Town Medical School, South Africa.

Clusin W T

Article Info

Journal

Annual review of medicine

Abbr.

Annu Rev Med

ISSN

0066-4219

DOI

10.1146/annurev.me.41.020190.001311

Published

1990-00-00

Pages

231-8

Language

English

Region

United States

NLM ID

2985151R

Subset

External Links

PubMed source DOI: 10.1146/annurev.me.41.020190.001311 View journal details

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Cellular mechanism for ischemic ventricular arrhythmias.

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