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题目:: IL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells.
作者:: Kim(Mi Sun),Kim(Won Sam),Piao(Zheng-Hao),Yun(Sohyun),Lee(Suk Hyung),Lee(Suui),Jeong(Mira),Sun(Hu-Nan),Park(Young-Jun),Jung(Haiyoung),Yoon(Suk Ran),Choi(Inpyo)
状态:: 发布时间2011-10-31 , 更新时间 2011-10-31
期刊:: Immunol Lett
摘要:: The IL-22 NKp46(+) innate lymphoid cells, NCR22 cells, are very important for the early host defense against microbial pathogens. We show here that NCR22 cells were differentiated from Lin(-)CD127(+)CD117(+) cells that were derived from hematopoietic precursor cells (HPCs) of mouse bone marrow cells. The combination of low concentrations of IL-23 and IL-15 induced differentiation of NCR22 cells from Lin(-)CD127(+)CD117(+) cells. NCR22 cells expressed a large amount of IL-22 and RORγt, and they had poor cytolytic activity and produced little IFN-γ. Lin(-)CD127(+)CD117(+) cells were very similar to intestinal lamina propria LTi-like cells; both cells dominantly expressed RORγt and IL-22. Meanwhile, Lin(-)CD127(-)CD117(+) cells that were also derived from HPCs did not express RORγt and IL-22, and they developed into conventional NK cells, not into NCR22 cells. These findings revealed that NCR22 cells can be differentiated from Lin(-)CD127(+)CD117(+) cells which are derived from HPCs.
语言:: eng
DOI:: 10.1016/j.imlet.2011.07.007

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