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PMID: 21814517 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.

PLoS genetics ·Vol. 7 ·No. 7 ·2011-07-00 ·Pages e1002170

Noguchi E, Sakamoto H, Hirota T, Ochiai K, Imoto Y, Sakashita M, Kurosaka F, Akasawa A, Yoshihara S, Kanno N, Yamada Y, Shimojo N, Kohno Y, Suzuki Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N, Sakamoto T, Masuko H, Nakamura Y, Nomura I, Tamari M, Arinami T, Yoshida T, Saito H, Matsumoto K

Abstract

Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(-8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10(-10), OR = 1.52, and DPB1*0901: P = 2.0×10(-7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.

MeSH Terms
Adolescent Alleles Asians/genetics Asthma/genetics Case-Control Studies Child Child, Preschool Female Gene Frequency Genetic Predisposition to Disease/genetics Genome-Wide Association Study HLA-DP Antigens/genetics HLA-DP alpha-Chains/genetics HLA-DP beta-Chains/genetics Haplotypes Humans Male Polymorphism, Single Nucleotide/genetics
Chemicals
HLA-DP Antigens HLA-DP alpha-Chains HLA-DP beta-Chains HLA-DPA1 antigen HLA-DPB1 antigen
Authors & Affiliations
34 authors, click to expand affiliations / ORCID
Noguchi Emiko
Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan.
Sakamoto Hiromi
Hirota Tomomitsu
Ochiai Kaori
Imoto Yoshimasa
Sakashita Masafumi
Kurosaka Fumitake
Akasawa Akira
Yoshihara Shigemi
Kanno Noriko
Yamada Yumi
Shimojo Naoki
Kohno Yoichi
Suzuki Yoichi
Kang Mi-Jin
Kwon Ji-Won
Hong Soo-Jong
Inoue Ken
Goto Yu-Ichi
Yamashita Fumio
Asada Takashi
Hirose Hiroshi
Saito Ikuo
Fujieda Shigeharu
Hizawa Nobuyuki
Sakamoto Toru
Masuko Hironori
Nakamura Yusuke
Nomura Ichiro
Tamari Mayumi
Arinami Tadao
Yoshida Teruhiko
Saito Hirohisa
Matsumoto Kenji
Conflict of Interest

The authors have declared that no competing interests exist.

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Article Info
Journal
PLoS genetics
Abbr.
PLoS Genet
ISSN
1553-7404
DOI
10.1371/journal.pgen.1002170
Published
2011-07-00
Epub
2011-00-21
Pages
e1002170
Language
English
Region
United States
NLM ID
101239074
PMCID
PMC3140987
Subset
IM
External Links
PubMed source DOI: 10.1371/journal.pgen.1002170 PMC Full Text View journal details
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