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PMID: 217706 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Glutamate and aspartate mimic the afferent transmitter in the cochlea.

Experimental brain research ·Vol. 34 ·No. 2 ·1979-01-15 ·Pages 389-93

Bobbin RP

Abstract

Glutamate (50 mM) and aspartate (50 mM) applied intracochlearly increase the spontaneous activity of ganglion cells of the auditory nerve. This activity may account for the decreased magnitude of the compound action potential observed with these substances in previous studies, and also may be additional evidence that these substances have a role in synaptic transmission between the hair cells and primary auditory afferent nerve cells.

MeSH Terms

Animals Aspartic Acid/pharmacology Auditory Pathways/drug effects Cochlear Nerve/drug effects Dose-Response Relationship, Drug Evoked Potentials/drug effects Glutamates/pharmacology Guinea Pigs Neurons, Afferent/drug effects Synapses/drug effects Synaptic Transmission/drug effects

Chemicals

Glutamates Aspartic Acid

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Bobbin R P

References (9)

9 references, click to expand

Amino acids - putative afferent transmitter in the cochlea?
Exp Brain Res. 1977 Oct 24;30(1):145-8 PMID: 201482
Effects of putative transmitters on afferent cochlear transmission.
Ann Otol Rhinol Laryngol. 1978 Mar-Apr;87(2 Pt 1):185-90 PMID: 206175
Evidence that 5-HT is not the afferent transmitter in the cochlea.
Exp Brain Res. 1977 Oct 24;30(1):141-3 PMID: 201481
Effects of divalent ions and drugs on synaptic transmission in phasic electroreceptors in a mormyrid fish.
J Gen Physiol. 1971 Nov;58(5):580-98 PMID: 4330695
The pharmacology of transmission in the peripheral auditory system.
Pharmacol Rev. 1976 Jun;28(2):95-125 PMID: 188055
Levels of putative transmitter amino acids in the guinea pig cochlea.
J Histochem Cytochem. 1976 Feb;24(2):468-70 PMID: 1254943
Efferent innervation of vestibular and auditory receptors.
Physiol Rev. 1974 Apr;54(2):316-57 PMID: 4362161
Evidence that catecholamines are not the afferent transmitter in the cochlea.
Exp Brain Res. 1977 Jun 27;28(3-4):315-24 PMID: 195827
Evidence that GABA is not the afferent transmitter in the cochlea.
Exp Brain Res. 1977 Jun 27;28(3-4):311-4 PMID: 885181

Article Info

Journal

Experimental brain research

Abbr.

Exp Brain Res

ISSN

0014-4819

DOI

10.1007/BF00235683

Published

1979-01-15

Pages

389-93

Language

English

Region

Germany

NLM ID

0043312

Subset

External Links

PubMed source DOI: 10.1007/BF00235683 View journal details

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Glutamate and aspartate mimic the afferent transmitter in the cochlea.

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