A GAP in our knowledge of vascular signaling in acute kidney injury.
作者:
Basile(David P)
状态:
发布时间2011-07-15
, 更新时间 2016-10-25
期刊:
Kidney Int
摘要:
Injury resulting from ischemia-reperfusion injury is a multifactorial process involving compromised function in both the tubular and the vascular compartments. Multiple vasoactive compounds have been implicated in the profound vasoconstriction that occurs in response to ischemia-reperfusion injury, and many of these factors signal through common G protein-coupled receptors. The report by Siedlecki et al. highlights the important roles of RGS4, a GTPase-accelerating protein (GAP), in the regulation of vascular tone in the setting of acute kidney injury.