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题目:: Detection of HTLV-I proviral sequences in CD30-positive large cell cutaneous T-cell lymphomas.
作者:: Anagnostopoulos(I),Hummel(M),Kaudewitz(P),Herbst(H),Braun-Falco(O),Stein(H)
状态:: 发布时间1991-01-25 , 更新时间 2013-10-02
期刊:: Am J Pathol
摘要:: To investigate the possibility that cutaneous T-cell lymphomas of large cell type may be associated with human T-cell leukemia/lymphoma virus type I infection in nonendemic regions, tissue samples from six cases of large cell cutaneous T-cell lymphoma and four cases of small cell cutaneous T-cell lymphoma were screened for the presence of integrated proviral human T-cell leukemia/lymphoma virus type I DNA. Combined use of Southern blot hybridization and enzymatic DNA amplification revealed human T-cell leukemia/lymphoma virus type I-specific sequences in all cases of large cell cutaneous T-cell lymphoma and in none of the cases of small cell cutaneous T-cell lymphoma. These results suggest that in nonendemic areas, a significant proportion of large cell cutaneous T-cell lymphoma cases are associated with human T-cell leukemia/lymphoma virus type I.
语言:: eng
DOI:

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