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PMID: 21732472 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

A spatial view of the CD8+ T-cell response: the case of HCV.

Reviews in medical virology ·Vol. 21 ·No. 6 ·2011-11-00 ·Pages 347-57

Racanelli V, Leone P, Grakoui A

Abstract

In viral infections, a memory T-cell population comprises multiple subtypes of cells, distributed in diverse anatomic compartments and possibly re-circulating among them. Accordingly, memory T cells display distinct phenotypes and functions, depending on the nature of the infecting virus, the anatomic location of the infection, and the differences between the sites of active infection and T-cell collection. This paper explores the body compartments where virus-specific CD8(+) T cells have been found during chronic hepatitis C virus infection, describes the cells' memory qualities, and discusses how they are spatially regulated, in comparison with other human viral infections. Understanding the role of compartmentalization and diversity of HCV-specific memory T-cell subsets may be the key to developing effective immunotherapies.

MeSH Terms
CD8-Positive T-Lymphocytes/immunology Hepacivirus/immunology Hepatitis C, Chronic/immunology Humans Immunologic Memory T-Lymphocyte Subsets/immunology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Racanelli Vito
Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy. v.racanelli@dimo.uniba.it
Leone Patrizia
Grakoui Arash
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Article Info
Journal
Reviews in medical virology
Abbr.
Rev Med Virol
ISSN
1099-1654
DOI
10.1002/rmv.702
Email
v.racanelli@dimo.uniba.it
Published
2011-11-00
Epub
2011-00-05
Pages
347-57
Language
English
Region
England
NLM ID
9112448
PMCID
PMC3549591
Subset
IM
Grants
NIDDK NIH HHS · R01 DK083356 · United States
NIDDK NIH HHS · R01 DK083356-01A1 · United States
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NIAID NIH HHS · R01 AI070101 · United States
NIDDK NIH HHS · R01 DK083356-03 · United States
NIDDK NIH HHS · DK083356 · United States
NIAID NIH HHS · R01 AI070101-05 · United States
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NIAID NIH HHS · AI070101 · United States
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NIAID NIH HHS · R01 AI070101-01 · United States
NIDDK NIH HHS · R01 DK083356-02 · United States
External Links
PubMed source DOI: 10.1002/rmv.702 PMC Full Text View journal details
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