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PMID: 21659547 Published · ppublish English Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative study.

Blood ·Vol. 118 ·No. 6 ·2011-08-11 ·Pages 1675-84

Moratto D, Giliani S, Bonfim C, Mazzolari E, Fischer A, Ochs HD, Cant AJ, Thrasher AJ, Cowan MJ, Albert MH, Small T, Pai SY, Haddad E, Lisa A, Hambleton S, Slatter M, Cavazzana-Calvo M, Mahlaoui N, Picard C, Torgerson TR, Burroughs L, Koliski A, Neto JZ, Porta F, Qasim W, Veys P, Kavanau K, Hönig M, Schulz A, Friedrich W, Notarangelo LD

Abstract

In this retrospective collaborative study, we have analyzed long-term outcome and donor cell engraftment in 194 patients with Wiskott-Aldrich syndrome (WAS) who have been treated by hematopoietic cell transplantation (HCT) in the period 1980- 2009. Overall survival was 84.0% and was even higher (89.1% 5-year survival) for those who received HCT since the year 2000, reflecting recent improvement of outcome after transplantation from mismatched family donors and for patients who received HCT from an unrelated donor at older than 5 years. Patients who went to transplantation in better clinical conditions had a lower rate of post-HCT complications. Retrospective analysis of lineage-specific donor cell engraftment showed that stable full donor chimerism was attained by 72.3% of the patients who survived for at least 1 year after HCT. Mixed chimerism was associated with an increased risk of incomplete reconstitution of lymphocyte count and post-HCT autoimmunity, and myeloid donor cell chimerism < 50% was associated with persistent thrombocytopenia. These observations indicate continuous improvement of outcome after HCT for WAS and may have important implications for the development of novel protocols aiming to obtain full correction of the disease and reduce post-HCT complications.

MeSH Terms
Autoimmunity/immunology Blood Donors Cell Lineage Child Child, Preschool Follow-Up Studies Hematopoietic Stem Cell Transplantation/adverse effects,methods Humans Mutation Outcome Assessment, Health Care/statistics & numerical data Postoperative Complications/blood,etiology,immunology Retrospective Studies Survival Analysis Thrombocytopenia/blood,etiology Time Factors Transplantation Chimera/blood Wiskott-Aldrich Syndrome/blood,genetics,surgery
Authors & Affiliations
31 authors, click to expand affiliations / ORCID
Moratto Daniele
A. Nocivelli Institute for Molecular Medicine, Pediatric Clinic, University of Brescia, and Laboratory of Genetic Disorders of Childhood, Spedali Civili, Brescia, Italy.
Giliani Silvia
Bonfim Carmem
Mazzolari Evelina
Fischer Alain
Ochs Hans D
Cant Andrew J
Thrasher Adrian J
Cowan Morton J
Albert Michael H
Small Trudy
Pai Sung-Yun
Haddad Elie
Lisa Antonella
Hambleton Sophie
Slatter Mary
Cavazzana-Calvo Marina
Mahlaoui Nizar
Picard Capucine
Torgerson Troy R
Burroughs Lauri
Koliski Adriana
Neto Jose Zanis
Porta Fulvio
Qasim Waseem
Veys Paul
Kavanau Kristina
Hönig Manfred
Schulz Ansgar
Friedrich Wilhelm
Notarangelo Luigi D
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Article Info
Journal
Blood
Abbr.
Blood
ISSN
1528-0020
Published
2011-08-11
Epub
2011-00-09
Pages
1675-84
Language
English
Region
United States
NLM ID
7603509
PMCID
PMC3156052
Subset
IM
Grants
NICHD NIH HHS · R37 HD017427 · United States
Wellcome Trust · 090233 · United Kingdom
NIAID NIH HHS · U54 AI082973 · United States
NHLBI NIH HHS · 5P01HL059561-12 · United States
NHLBI NIH HHS · 2P01HL059561-11-A1 · United States
NIAID NIH HHS · U54 AI082973-02 · United States
Medical Research Council · G0701897 · United Kingdom
NHLBI NIH HHS · P01 HL036444 · United States
NHLBI NIH HHS · P01 HL059561 · United States
NICHD NIH HHS · HD17427-43 · United States
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