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PMID: 21654879 Published · ppublish English Journal Article

The roles of EZH2 in cell lineage commitment.

American journal of translational research ·Vol. 3 ·No. 3 ·2011-05-15 ·Pages 243-50

Chou RH, Yu YL, Hung MC

Abstract

Enhancer of zeste homolog 2 (EZH2), a catalytic component of polycomb repressive complex 2 (PRC2), epigenetically regulates chromatin structure and gene expressions through tri-methylation at histone H3K27 and recruitment of DNA methyltransferases for gene silencing. Despite extensive studies of the role of EZH2 in cancer progression and malignancy, increasing evidence also suggest that EZH2 plays a critical role in stem cells renewal, maintenance, and differentiation into specific cell lineages. Here, we review the updated information regarding how EZH2 contributes to stem cell maintenance, cell lineage determination, including myogenesis, adipogenesis, osteogenesis, neurogenesis, hematopoiesis, lymphopoiesis, epidermal differentiation and hepatogenesis, and how EZH2 is regulated by phosphorylation and microRNAs in these processes.

Keywords
EZH2 cell lineage differentiation stem cells
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chou Ruey-Hwang
Yu Yung-Luen
Hung Mien-Chie
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Article Info
Journal
American journal of translational research
Abbr.
Am J Transl Res
ISSN
1943-8141
Published
2011-05-15
Epub
2011-00-21
Pages
243-50
Language
English
Region
United States
NLM ID
101493030
PMCID
PMC3102568
Grants
NCI NIH HHS · P01 CA099031 · United States
NCI NIH HHS · R01 CA109311 · United States
External Links
PubMed source PMC Full Text View journal details
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