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PMID: 21643977 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Decreased expression of lysosomal alpha-galactosiase A gene in sporadic Parkinson's disease.

Neurochemical research ·Vol. 36 ·No. 10 ·2011-10-00 ·Pages 1939-44

Wu G, Huang J, Feng X, Zhang A, Li J, Pang S, Gu K, Dong H, Zhang J, Gao H, Yan B

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease. To date, the causal genes and variants associated with sporadic PD are largely unknown. Accumulating evidence demonstrates that autophagy delivers alpha-syncuclein proteins to lysosome for degradation and dysfunctional autophagy is involved in the PD pathogenesis. We have previously screened a group of lysosomal hydrolases and found that alpha-galactosidase A (GLA) activity is significantly decreased in the peripheral leukocytes of sporadic PD patients. In this study, GLA transcript and protein levels were semi-quantitatively examined. The GLA transcript (P = 0.020) and protein (P = 0.027) levels in the peripheral leukocytes of sporadic PD patients were significantly decreased, compared to age- and sex-matched healthy controls. Furthermore, decreased GLA gene expression levels were strongly associated with sporadic PD (OR 3.33, 95%CI 1.17-9.52, P = 0.024). Therefore, our data suggest that insufficient GLA activity may contribute to the pathogenesis of sporadic PD. The underlying molecular mechanisms remain to be determined.

MeSH Terms
Aged Gene Expression Regulation, Enzymologic Genetic Predisposition to Disease Humans Leukocytes/enzymology Lysosomes/enzymology Male Middle Aged Parkinson Disease/enzymology,genetics,physiopathology alpha-Galactosidase/genetics,metabolism
Chemicals
alpha-Galactosidase
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Wu Guanghua
Division of Cardiac Surgery, Jining Medical College Affiliated Hospital, Jining Medical College, 79 Guhuai Road, Jining, Shandong 272029, China.
Huang Jian
Feng Xungang
Zhang Aimei
Li Jifeng
Pang Shuchao
Gu Kejin
Dong Haixin
Zhang Junping
Gao Huijie
Yan Bo
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
1573-6903
DOI
10.1007/s11064-011-0516-0
Published
2011-10-00
Epub
2011-00-05
Pages
1939-44
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1007/s11064-011-0516-0 View journal details
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