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PMID: 21605374 Published · epublish English Comment Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

BMC medicine ·Vol. 9 ·2011-05-23 ·Pages 62

Sotgia F, Martinez-Outschoorn UE, Lisanti MP

Abstract

The functional role of oxidative stress in cancer pathogenesis has long been a hotly debated topic. A study published this month in BMC Cancer by Goh et al., directly addresses this issue by using a molecular genetic approach, via an established mouse animal model of human breast cancer. More specifically, alleviation of mitochondrial oxidative stress, via transgenic over-expression of catalase (an anti-oxidant enzyme) targeted to mitochondria, was sufficient to lower tumor grade (from high-to-low) and to dramatically reduce metastatic tumor burden by >12-fold. Here, we discuss these new findings and place them in the context of several other recent studies showing that oxidative stress directly contributes to tumor progression and metastasis. These results have important clinical and translational significance, as most current chemo-therapeutic agents and radiation therapy increase oxidative stress, and, therefore, could help drive tumor recurrence and metastasis. Similarly, chemo- and radiation-therapy both increase the risk for developing a secondary malignancy, such as leukemia and/or lymphoma. To effectively reduce mitochondrial oxidative stress, medical oncologists should now re-consider the use of powerful anti-oxidants as a key component of patient therapy and cancer prevention. Please see related research article: http://www.biomedcentral.com/1471-2407/11/191.

MeSH Terms
Animals Antineoplastic Agents/therapeutic use Antioxidants/therapeutic use Breast Neoplasms/drug therapy,pathology Catalase/genetics,metabolism Disease Models, Animal Female Gene Expression Humans Mice Mitochondria/metabolism Neoplasm Metastasis/pathology,prevention & control Neoplasms/drug therapy,pathology Oxidative Stress Protein Transport Rodent Diseases/drug therapy,pathology
Chemicals
Antineoplastic Agents Antioxidants Catalase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sotgia Federica
The Jefferson Stem Cell Biology and Regenerative Medicine Center, Philadelphia, PA, USA.
Martinez-Outschoorn Ubaldo E
Lisanti Michael P
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Article Info
Journal
BMC medicine
Abbr.
BMC Med
ISSN
1741-7015
Published
2011-05-23
Epub
2011-00-23
Pages
62
Language
English
Region
England
NLM ID
101190723
PMCID
PMC3123229
Subset
IM
Grants
NIAMS NIH HHS · R01-AR-055660 · United States
NCI NIH HHS · R01-CA-080250 · United States
NCI NIH HHS · R01-CA-098779 · United States
NCI NIH HHS · R01-CA-120876 · United States
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