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PMID: 2158762 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Immune suppression by herpesviruses.

Annual review of medicine ·Vol. 41 ·1990-00-00 ·Pages 331-8

Rinaldo CR

Abstract

A unifying theme among the herpesviruses is the intimate interrelationship of virus infection with host cellular immune competence. Herpesviruses suppress cellular immunity. Recent advances suggest mechanisms of herpesvirus-induced immunosuppression that include inhibition of cytokine production and direct interaction of virus with major histocompatibility complex (MHC) components. This suppression appears to be of clinical significance primarily in patients with underlying immune deficiencies.

MeSH Terms

Cytomegalovirus Infections/immunology Herpesviridae Infections/immunology Herpesvirus 4, Human Humans Immune Tolerance

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Rinaldo C R

Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania 15261.

Article Info

Journal

Annual review of medicine

Abbr.

Annu Rev Med

ISSN

0066-4219

DOI

10.1146/annurev.me.41.020190.001555

Published

1990-00-00

Pages

331-8

Language

English

Region

United States

NLM ID

2985151R

Subset

Grants

NIAID NIH HHS · N01-AI-32513 · United States

NIAID NIH HHS · N01-AI-72632 · United States

NIAID NIH HHS · R01-AI-16212 · United States

External Links

PubMed source DOI: 10.1146/annurev.me.41.020190.001555 View journal details

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